U. Sani, M. Yahaya
2016
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Journal
ChemSearch Journal
Abstract
2-[(2-hydroxyphenyl)methylidene]hydrazine-1-carbothioamide was obtained by the condensation of salicyldehyde and thiosemicarbazone. Ni(II) and Cu(II) complexes were prepared and characterized by elemental (CHNOSO) analysis, FTIR, UV – visible, magnetic susceptibility, and molar conductance measurements. The ligand sharp peak at 1616cm -1 in the FTIR spectra indicating the formation of azomethine (-C=N-) bond. A shift shows band to the band regions 1597cm -1 and 1510cm -1 confirmed the coordination of the azomethine nitrogen with Nickel(II) and Cu(II) ions respectively. The ligand formed a chelate with 1:2 metal : ligand stoichiometry. All the compounds have been screened for antibacterial and antifungal activity by disc diffusion method against Staphylococcus aureus , Escherichia coli and Salmonella typhi as well as Aspergillus flavus bacterial and fungal isolates respectively. The compounds are found to be active against the tested isolates. Keywords: Schiff base, Chacterisation, Ligand, Antibacterial, Antifungal