Synthesis, characterization and biological activity of diphenyltin(IV) complexes of N‐(3,5‐dibromosalicylidene)‐α‐amino acid and their diphenyltin dichloride adducts

doi:10.1002/AOC.1005

Paper

Synthesis, characterization and biological activity of diphenyltin(IV) complexes of N‐(3,5‐dibromosalicylidene)‐α‐amino acid and their diphenyltin dichloride adducts

Published 2006 · Laijin Tian, Z. Shang, Xiao‐Feng Zheng

Applied Organometallic Chemistry

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Abstract

Diphenyltin(IV) complexes of N-(3,5-dibromosalicylidene)-α-amino acid, Ph2Sn[3,5-Br2-2-OC6H2 CHNCH(R)COO] (where R = H, Me, i-Pr, Bz), and their 1:1 adducts with diphenyltin dichloride, Ph2Sn[3,5-Br2-2-OC6H2CHNCH(R)COO]·Ph2SnCl2, have been synthesized and characterized by elemental analysis, IR and NMR (1H, 13C and 119Sn) spectra. The crystal structure of Ph2Sn[3,5-Br2-2-OC6H2CHNCH(i-Pr)COO] shows a distorted trigonal bipyramidal geometry with the axial locations occupied by a carboxylate–oxygen and a phenolic–oxygen atom of the ligand, and that of Ph2Sn[3,5-Br2-2-OC6H2CHNCH(i-Pr)COO]·Ph2SnCl2 reveals that the two tin atoms are joined via the carbonyl atom of the ligand to form a mixed organotin binuclear complex. Bioassay indicates that the compounds possess better cytotoxic activity against three human tumor cell lines (HeLa, CoLo205 and MCF-7) than cis-platin and moderate antibacterial activity against two bacteria (E. coli and S. aureus). Copyright © 2005 John Wiley & Sons, Ltd.

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Diphenyltin(IV) complexes of N-(3,5-dibromosalicylidene)--amino acid show better cytotoxic activity against human tumor cell lines than cis-platinum and moderate antibacterial activity against E. coli and S. aure

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, characterization and biological activity of diphenyltin(IV) complexes of N‐(3,5‐dibromosalicylidene)‐α‐amino acid and their diphenyltin dichloride adducts

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References

Citations

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Diorganotin complexes with Schiff bases derived from salicylaldehyde and l-tyrosine show moderate antibacterial activity and efficient cytostatic activity against human tumor cell lines.

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