Paper
Synthesis, characterization, biological activity of Schiff bases derived from 3-bromo-4-methyl aniline and its potentiometric studies with Cu(II), Co(II) and Ni(II) ions
Published May 10, 2020 · Surbhi V. Upadhyay, Raksha V. Zala, K. Bhatt
Letters in Applied NanoBioScience
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Abstract
Schiff bases namely, 3-bromo-4-methyl-N-(2-nitrobenzylidene)aniline; 3-bromo-4-methyl-N-(2,4,5-trimethoxybenzylidene)aniline; 3-bromo-N-(4-methoxybenzylidene)-4-methylaniline and N-(3-bromo-4-methylphenyl)-1-(1H-indol-3-yl)methanimine have been synthesized and characterized by elemental analysis, FT-IR, Mass and 1H-NMR spectroscopy. Schiff bases have been screened for Antimicrobial activity against bacteria and fungi by using MIC determination. Binary complexes of Co(II), Ni(II) and Cu(II) with Schiff bases in solution have been studied potentiometrically in 60:40 % (V/V) 1,4-dioxane-water system at constant temperature 27˚±0.5˚C and at an ionic strength of 0.1 M KNO3. The order of stability constant of formed binary complexes in solution was examined.
Schiff bases derived from 3-bromo-4-methyl aniline show antimicrobial activity against bacteria and fungi, and their stability constants in binary complexes with Cu(II), Ni(II), and Cu(II) ions were studied.
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