Synthesis, Characterization, Antibacterial, Antifungal and Anticancer Studies of a New Antimetabolite: N-((Diphenylamino)methyl)acetamide and Some of its Inner Transition Metal Chelates

doi:10.7598/CST2013.335

Paper

Synthesis, Characterization, Antibacterial, Antifungal and Anticancer Studies of a New Antimetabolite: N-((Diphenylamino)methyl)acetamide and Some of its Inner Transition Metal Chelates

Published Apr 18, 2013 · L. MURUGANANDAM L. MURUGANANDAM, K. Kumar, K. Balasubramania

Chemical science transactions

UNKNOWN SJR score

5

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Abstract

N-((Diphenylamino)methyl)acetamide was synthesized using Mannich reaction and its complexes of cerium(IV), thorium(IV) and dioxouranium(VI) were prepared and characterized by elemental analysis and various spectral studies. The bidendate chelation of ligand, bonding through carbonyl oxygen and azomethine nitrogen is suggested. Based on spectral and magnetic studies, hexa coordinate geometry is assigned for all the complexes. The complexes were screened for their antibacterial, antifungal and anticancer activities. They show positive results.

Study Snapshot

N-((Diphenylamino)methyl)acetamide shows promising antibacterial, antifungal, and anticancer activities when complexed with cerium(IV), thorium(IV), and dioxouranium(VI).

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, Characterization, Antibacterial, Antifungal and Anticancer Studies of a New Antimetabolite: N-((Diphenylamino)methyl)acetamide and Some of its Inner Transition Metal Chelates

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References

Mannich Bases-Chemistry and Uses

Mannich bases are essential for the synthesis and chemistry of natural products, and their practical applications in various industrial fields.

Infrared and Raman Spectra of Inorganic and Coordination Compounds

Inorganic molecules and ligands are classified into various groups, and their structures and infrared/Raman spectra are shown for various compounds.

Citations

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A NEW MANNICH BASE N-[PHENYL(PYRROLIDIN-1- YL)METHYL]ACETAMIDE - SYNTHESIS, SPECTRAL PROPERTIES, ANTIBACTERIAL AND ANTIFUNGAL STUDIES OF SOME OF ITS METAL COMPLEXES

The new Mannich base ligand PBA shows potential as an antibacterial and antifungal agent, with potential for use in pharmaceuticals.

Synthesis of new anti-bacterial agents: Hydrazide Schiff bases of vanadium acetylacetonate complexes

Schiff base complexes 1A and 1B show antimicrobial activity against both Escherichia coli and Klebsiella pneumoniae, with MIC values ranging from 305.3 to 378.9 mg/mL.

SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SOME NEW MANNICH BASES

The newly synthesized Mannich bases show significant antibacterial and antifungal activities against various pathogenic bacteria and fungi.