Synthesis, Characterization and Antimicrobial Activity of 4-Benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide

doi:10.12966/JSMR.03.02.2014

Paper

Synthesis, Characterization and Antimicrobial Activity of 4-Benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide

Published 2014 · D. Hagel, Agata Paneth, T. Plech

UNKNOWN SJR score

2

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide was synthesised by reacting pyrazine-2-carboxylic acid hydrazide with benzoylisothiocyanate in the presence of diethyl ether. Antibacterial activity was tested against Gram-positive and Gram-negative strains and antifungal action was examined towards Candida spp. The results showed that antibacterial activity against Gram-positive and Gram-negative bacteria expressed as minimal inhibitory concentration (MIC) ranged from 25 to 100 μg/mL and from 100 to 200 μg/mL, respectively. The compound exhibited also antifungal potency with MIC ranged between 50 and 200 μg/mL.

In Vitro Study

Study Snapshot

4-Benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide shows antibacterial and antifungal activity against Gram-positive and Gram-negative bacteria, with MIC ranges between 50 and 200 g/mL.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis, Characterization and Antimicrobial Activity of 4-Benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide

Sign up to use Study Snapshot

References

Fluoroquinolone-Gyrase-DNA Complexes

Two fluoroquinolone-binding modes exist in cleaved complexes containing gyrase, providing new ways to investigate inhibitor-topoisomerase interactions.

Antifungal effect of 4-arylthiosemicarbazides against Candida species. Search for molecular basis of antifungal activity of thiosemicarbazide derivatives

4-arylthiosemicarbazides show antifungal activity against Candida species, with isoquinoline derivatives showing more favorable affinity for the target NMT.

Synthesis and structure-activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides.

4-arylthiosemicarbazides show antibacterial activity against Gram-positive bacteria and topoisomerase IV inhibition, with their inhibitory activity linked to electronic structure rather than molecule geometry.

Antimicrobial activity and SAR study of some novel thiosemicarbazide derivatives bearing piperidine moiety.

Novel thiosemicarbazide derivatives bearing piperidine moiety show potential antibacterial and antifungal activities, with significant molecular descriptors related to their antifungal activity.

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

New antibacterials targeting DNA gyrase are needed due to bacterial resistance to current drugs, and new inhibitory modes are needed to combat this issue.

Citations

GREEN SYNTHESIS AND EVALUATION OF BIOLOGICAL IMPACT OF Zn(II), Cd(II) AND Hg(II) COMPLEXES WITH PHENYLACETYLUREA AND BUTANOATE ION LIGANDS Original Article

Zn(II), Cd(II), and Hg(II) complexes with phenylacetyl urea and butanoate ligands show higher biological activities and antibacterial and antifungal properties compared to pure PAU and butanoate ligands.

ECO-FRIENDLY PREPARATION AND BIOLOGICAL ASSESMENT OF Cr(III), Mn(II) AND Fe(III) COMPLEXES WITH PHENYLACETYLUREA AND BUTANOATE ION LIGANDS

The Fe(III) complex shows higher antibacterial activity than Cr(III) and Mn(II) complexes, but all three complexes show low antifungal activity compared to ketokonazole.