V. K. Salvi, Gangotri Pemawat, Archita Bapna
Jan 12, 2010
Citations
0
Influential Citations
1
Citations
Journal
ChemInform
Abstract
Hydrozinolysis of phthalyl derivatives of amino acid 1a-c afforded [(4-oxo-3,4-dihydrophthalazine-1-yl)amino]substituted acetic acid 2a-c, which on reaction with POCl 3 /PCl 5 gave [(4-chlorophthalazine-1-yl)aminolsubstituted acetic acid 3a-c. This when condensed with N-hydroxyphthalimide/N-hydroxysuccinimide 4a-b yielded phthalimido or succinimido-2-({4-phthalazine-1-yl}amino)substituted acetic acid 5a-f. Condensation of compounds 2a-c with ωbromoalkoxyphthalimide 6a-b furnished the corresponding 2-[(3-{2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]ethyl}-4-oxo-3,4-dihydrophthalazine-1-yl)amino]substituted acetic acid 7a-f. All the compounds were screened for antimicrobial activities.