Sunil Vodela, Venu Chakravarthula
Dec 9, 2016
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Influential Citations
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Journal
Journal of Drug Delivery and Therapeutics
Abstract
A simple and convenient method has been developed for the synthesis of title compounds, 1-methyl-2-phenyl-1 H -imidazo[4,5- f ]-quinoline and derivatives (5a-f) in reasonable yields. The commercially available 6-nitro-quinoline-5-amine (1) is used as raw material and it is reduced conveniently using SnCl 2 to give the initial intermediate, quinoline-5,6-diamine (2) in good yield. Compound 2 on consecutive steps when treated on condensation followed by cyclization generated the rest of intermediates, N 6 -benzylidene-quinoline-5,6-diamines (3a-f) and 2-phenyl-1 H -imidazo[4,5- f ]-quinolines (4a-f) respectively. The chemical structures of all newly prepared compounds were elucidated using infrared, 1 H NMR and mass spectral studies as well as elemental analysis. The output of this synthetic method has been provided a series of successful biologically important structures. Keywords: Quinoline, imidazole, antimicrobial activity