S. Muralikrishna, P. Raveendrareddy, L. Ravindranath
Sep 30, 2014
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Journal
British Biomedical Bulletin
Abstract
Purpose: The article is aimed to synthesize,characterize and screening the biological activity of a series of Synthesis of 1-(2-(3-(3-chloro-1-(4-substituted phenyl)-4-tetrazole-2-yl)-1H-indol-1-yl)acetyl)-4-(2-(4substituted phenyl)hydrazono)-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one 4(a-f). Indole-3-carbaldehyde and chloro ethyl acetate were dissolved in DMF. To this reaction mixture anhydrous K2CO3 was added and the reaction mixture was stirred at room temperature(350C) for 8 hours. To afford 2-(3-formyl-1Hindol-1-yl)acetate. To this reaction mixture added aniline,EtoH and three drops of acetic acid is added and then heated on a steam bath for 5-6 hrs.Compound(A) Ethyl 2-(3-phenyl imino)methyl-1H-Indole-1-ylacetate was obtained. Compound(A) is converted into Ethyl2-(3-(1-phenyl-1H-tetrazol-5-yl)-1H-indol-1yl)acetate (1) by using of conditions (1)PCl3,1000C,1hr (2)NaN3(ice cold),ZnCl2,Sodium acetate,acetone,water,RT. Schiff base synthesis of thiazole derivatives containing Indole moiety bearing tetrazole ring were synthesised by the condensation of 2-(3-(3-chloro -1-(4-substitued phenyl )-4tetrazole -2-yl)-1H-Indole –1-yl) Aceto hydrazide with potassium thio cyanide and substituted ketones. Then 1-(2-(3-(3-chloro-1-(4-substituted phenyl)-4-tetrazole-2-yl)-1H-indol-1-yl)acetyl)-4-(2-(4substituted phenyl)hydrazono)-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one is obtained. The structure of these newly synthesized compounds were characterized by 1 H NMR, 13 CNMR ,Mass ,IR, and elemental analysis. The antimicriobial activity of the novel compounds was screened by agar discdiffusion method.