B. J. Mohan, B. Sarojini, B. Narayana
2014
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Abstract
A novel pyrimidine derivative ethyl 4-(4-(benzyloxy)phenyl)-6-methyl-2-oxo-1,2,3,4- tetra hydro pyrimi- dine-5-carboxylate (4) was synthesized by Biginelli three component cyclocondensation reaction in presence of a catalyst SiCl4 in good yield and characterized by IR, 1 H NMR, 13 C NMR, LCMS and elemental analysis. The compound 4 was screened for in vitro antioxidant activity using DPPH radical, hydroxyl radical scavenging assay. The in vivo radioprotection property of compound 4 was determined by assaying on Drosophila melanogaster model system; inducing oxidative stress in flies at 3Gy electron beam irradiation. The flies treated with the compound prior to irradiation showed reduction in oxidative stress caused by ionizing e-beam radiation.