R. Frutos, G. Roth
Dec 2, 1997
Citations
0
Influential Citations
4
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A route towards the synthesis of a ranitidine bulk drug product impurity is described. This protocol involves acetyl chloride initiated oxonium ion generation and subsequent trapping to form the corresponding ranitidine dimer ( 1 ). This synthesis allowed for structure verification of the impurity and provided reference supplies for further analytical and toxicology investigations.