N. Desai, P. N. Shihora, D. Moradia
Mar 1, 2007
Citations
0
Influential Citations
16
Citations
Journal
ChemInform
Abstract
Ethyl 4-[2-(2-chlorophenyl)-4-oxo-3-hydroquinazolin-3yl]-benzoate 1 which reacts with hydrazine hydrate in presence of methanol resulted into N -amino{4 -[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3-yl)phenyl}carboxamide 2. Compound 2 on treatment with aryl isothiocyanates in presence of acetone is converted into aryl-N-{[({4-[2- (2-chlorophenyl)-4-oxo(3-hydroquinazolin-3-yl)]phenyl } carbonylamino)amino]thioxo methyl)-amides 3. Compound 3, in presence of sulphuric acid has yielded aryl-N -(5-{4-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3-yl)]-phenyl}(1,3,4,thiadiazol -2-yl))amides 4a-I. Newly synthesized compounds 4a-I have been screened for their antibacterial and antifungal activities on Eschericia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, C. albicans, A. niger and A. clavatus.