P. Mohite, V. Bhaskar
Jul 1, 2010
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Iranian Journal of Pharmaceutical Sciences
Abstract
Reaction of 5-phenyl tetrazole with ethyl chloroacetate to form ethyl (5-phenyl- 1H -tetrazol-1-yl) acetate (1). Compound 1 react with hydrazine hydrate in ethanol yield 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (2). The condensation of (2) with various aldehydes yield the corresponding substituted N'-(-arylidene)-2-(5-phenyl- 1H-tetrazol-1-yl) acetohydrazide (3a- j). The compounds obtained were identified by spectral data and have been screened for antimicrobial activity. The most promising compounds having good antibacterial activity were 3b, 3c and 3i, and the best for antifungal activity were 3b, 3c and 3e. K eywords: Antimicrobial activity; Ciprofloxacin; Griseofulvin; Schiff's bases; Tetrazole.