Paper
Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity
Published Nov 25, 2015 · H. Sudhamani, S. Basha, N. Venkateswarlu
Journal of Chemical Sciences
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Abstract
AbstractA new class of antimicrobial and antioxidant agents, based on thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole were synthesized by adopting a simple and efficient method. Synthesized compounds were characterized by spectral data of IR, 1H, 13C NMR and mass spectra. The compounds were evaluated for their efficacy as antimicrobial and antioxidant agents. A few compounds showed good antibacterial, antifungal and antioxidant activity when compared to standard drugs and thus represent a new class of promising lead compounds. Graphical AbstractA new series of thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole were synthesized in a convenient way. The in vitro antimicrobial activity of the title compounds were screened against selected organisms by disc diffusion technique and the antioxidant activity were evaluated by H2O2 and DPPH Methods.
In Vitro StudyNew thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole show promising antibacterial, antifungal, and antioxidant activity compared to standard drugs.
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