G. Veeresa, A. Datta
Nov 12, 1998
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient synthesis of the widely used antibiotic chloramphenicol ( 1 ) is described. The key step in the synthesis involves chelation-controlled addition of phenylmagnesium bromide to a suitably protected D-serinal derivative, affording the pivotal D- threo 1,2-amino alcohol intermediate 3 in a highly stereoselective manner.