Synthesis of chloro and bromo substituted 5-(indan-1'-yl)tetrazoles and 5-(indan-1'-yl)methyltetrazoles as possible analgesic agents.

doi:10.1002/CHIN.200439118

Paper

Synthesis of chloro and bromo substituted 5-(indan-1'-yl)tetrazoles and 5-(indan-1'-yl)methyltetrazoles as possible analgesic agents.

Published Jun 1, 2004 · S. C. Bachar, S. Lahiri

Die Pharmazie

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Abstract

Chloro and bromo substututed indanyl tetrazoles (compounds 5a, b) and indanyl methyltetrazoles (compounds 5c, 5d) have been synthesized from their respective acids through amide and nitrile routes, and characterized. The title compounds (5a, 5b, 5c and 5d) were subjected for their analgesic activity in the acetic acid induced writhing test on albino mice. The significant (p < 0.001) analgesic activity, exhibited by the compound 5b at a dose of 50 mg/kg body weight, was comparable to that of phenylbutazone and indometacin at a dose of 100 and 50 mg/kg body weight respectively. The effect of substitution at the benzenoid part of the indan nucleus and chain lenght on analgesic activity was in the following order: bromine > chlorine and tetrazole > methyltetrazole.

Non-RCT

Animal Study

Study Snapshot

Chloro and bromo substituted indanyl tetrazoles show significant analgesic activity, comparable to phenylbutazone and indometacin, with bromine having a greater impact than chlorine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of chloro and bromo substituted 5-(indan-1'-yl)tetrazoles and 5-(indan-1'-yl)methyltetrazoles as possible analgesic agents.

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References

Citations

Nano-Catalytic Synthesis of 5-Substituted 1H Tetrazole Derivatives and Biological Applications

Nano-catalysts enhance the efficient and selective synthesis of 5-substituted 1H-tetrazole derivatives, offering potential as therapeutic agents due to their biological activity.

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New s-triazine/tetrazole conjugates show excellent antibacterial and antifungal activity, with potential for further optimization and drug-likeness properties.

Lung cancer growth inhibition and autophagy activation by tetrazole via ERK1/2 up-regulation and mTOR/p70S6K signaling down-regulation.

Tetrazole inhibits lung cancer cell growth by activating autophagy, deactivating ERK1/2 signaling, and promoting mTOR signaling in A549 and NCI-H1819 cells.

Anodyne activities of New Tetrazole derivatives from Triazine

Novel tetrazole derivatives (5a, 5b, and 5c) show analgesic activity, with compound 5c showing potent anodyne activity.

Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study

Novel tetrazole and cyanamide derivatives show potent anti-inflammatory and analgesic activities, with some showing equal or nearly the same ulcerogenic liability to celecoxib.