Synthesis, crystal structure, thermal analysis and biological activities of sodium 5-carboxy-2,3-dihydroxybenzenesulfonate

doi:10.1080/15421406.2015.1108149

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Synthesis, crystal structure, thermal analysis and biological activities of sodium 5-carboxy-2,3-dihydroxybenzenesulfonate

Published Apr 12, 2016 · J. Wei, K. Liu, F. Lin

Molecular Crystals and Liquid Crystals

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Abstract

ABSTRACT Through the sulfonation of protocatechuic acid, sodium 5-carboxy-2,3-dihydroxybenzenesulfonate (SPA) was synthesized. The structure of the sulfonated derivative was confirmed by FT-IR, MS, 1H NMR, 13C NMR, single crystal X-ray diffraction, and thermogravimetric analysis. The antioxidative activities of the derivative SPA were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging method and reducing power determination, showing that SPA had strong antioxidative effects. Meanwhile DPPH scavenging progress by SPA was analyzed from dynamics experiments. Isothermal titration calorimetry (ITC) and circular dichroism (CD) were applied to investigate the interaction between the derivative SPA and human serum albumin (HSA).

Study Snapshot

Sodium 5-carboxy-2,3-dihydroxybenzenesulfonate (SPA) has strong antioxidative effects and shows potential as a pharmaceutical agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis, crystal structure, thermal analysis and biological activities of sodium 5-carboxy-2,3-dihydroxybenzenesulfonate

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References

Fluorometric Investigation of the Interaction of (2E)-3-(4′-Halophenyl)-N-{4′′-[(5′′′,6′′′-dimethoxypyrimidin-4′′′-yl)sulfamoyl]phenyl}prop-2-enamides with Bovine Serum Albumin

The binding of p-halogenated cinnamic amides to bovine serum albumin changes the microenvironment around tyrosine residues, with three halogens having different effects on binding interactions.

Structural characterization and antioxidant activity of a heteropolysaccharide isolated from Hedysarum polybotrys

HPS3aS, a water-soluble polysaccharide isolated from Hedysarum polybotrys, shows good in vitro antioxidant activity, suggesting potential as a potential antioxidant.

Synthesis, characterization and interaction studies of copper based drug with Human Serum Albumin (HSA): spectroscopic and molecular docking investigations.

Copper complex 1, synthesized from dipeptide and sulfasalazine, strongly interacts with Human Serum Albumin (HSA) through hydrophobic and hydrogen bonding interactions, potentially offering a new treatment for thrombocytopenia.

Comparative spectroscopic studies on drug binding characteristics and protein surface hydrophobicity of native and modified forms of bovine serum albumin: possible relevance to change in protein structure/function upon non-enzymatic glycation.

Modified bovine serum albumins show altered drug binding characteristics and decreased protein surface hydrophobicity, potentially impacting drug distribution and drug-drug interactions in multi-drug therapy.

Effect of microwave treatment on phenolic content and antioxidant activity of citrus mandarin pomace.

Microwave treatment effectively liberates bound phenolic compounds and enhances the antioxidant activity of citrus mandarin pomace.

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