Wei Li, Q. Xiao, Ruchun Yang
Aug 1, 2014
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Journal
Advanced Materials Research
Abstract
The title compound, 1-(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione , C9H10FIN2O5, as potential drugs for anti-tumor, anti-viral have been synthesized and characterized by NMR spectra. Meanwhile, the crystal of 2b was obtained and determined by X-ray single-crystal diffraction. Crystal data: monoclinic system, space group P2(1), a = 9.0832(11) Ǻ, b = 5.4332(7) Ǻ, c = 12.2464(15) Ǻ, β = 107.809(4)°, V = 575.41(12) Ǻ3, Z = 2, F(000) = 360, Dx = 2.148 Mg m-3, μ = 2.813 mm-1, R = 0.014 and wR = 0.056 for 1988 independent reflections (Rint = 0.0209) and 1932 observed ones (I > 2σ (I)).