S. Asaftei, M. Reichelt, H. Reuter
Oct 1, 2009
Citations
0
Influential Citations
2
Citations
Journal
Helvetica Chimica Acta
Abstract
The 7-(2-bromoethyl) derivatives, 2a and 2b, of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1a) and 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (1b) were synthesized by nucleobase anion alkylation (NaH, DMF) and crystallized. X-Ray analyses of both compounds were performed, and they revealed significantly different positioning of the side chain relative to the heterocyclic ring, depending on the substituent (H or NH2) at C(2).