B. Danieli, G. Lesma, D. Passarella
Jan 20, 2004
Citations
0
Influential Citations
41
Citations
Journal
Organic letters
Abstract
[reaction: see text] The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.