Paper
Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
Published May 1, 2004 · Sang-hun Jung, Hui-Soon Lee, Nam-soo Kim
Archives of Pharmacal Research
Q1 SJR score
11
Citations
0
Influential Citations
Abstract
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4, 5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
Study Snapshot
The novel compounds 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones2) show highly potent and broad cytotoxicities against various cancers, with compound 2p showing a potent cytotoxicity even greater
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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