Synthesis and cytotoxicity of aminomethylselenopheno[3,2-b]thiophene sulfonamides

doi:10.1007/s10593-016-1930-7

Paper

Synthesis and cytotoxicity of aminomethylselenopheno[3,2-b]thiophene sulfonamides

Published Sep 27, 2016 · P. Arsenyan, K. Rubina, I. Domracheva

Chemistry of Heterocyclic Compounds

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Abstract

The reaction of 5-[(aminomethyl)ethynyl]thiophene-2-sulfonamides with in situ generated selenium(IV) chloride was used to synthesize 5-aminomethyl-substituted 6-chloroselenopheno[3,2-b]thiophene-2-sulfonamides. The cytotoxicity of these compounds was studied against HT-1080 (human fibrosarcoma), MH-22A (mouse hepatoma), CCL-8 (mouse sarcoma), MES-SA (human uterine sarcoma), MCF-7 (estrogen receptor-positive human breast adenocarcinoma) cell lines, as well as the normal NIH 3T3 cell line (mouse fibroblasts).

Study Snapshot

Aminomethylselenopheno[3,2-b]thiophene sulfonamides show promising cytotoxicity against various cancer cell lines, suggesting potential as a new cancer drug.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and cytotoxicity of aminomethylselenopheno[3,2-b]thiophene sulfonamides

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