Synthesis of bifunctional derivatives from 2,5-dimethylthiophene: Communication 2. Action of amines of 3,4-bischloromethyl-2,5-dimethylthiophene

doi:10.1007/BF01131068

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Synthesis of bifunctional derivatives from 2,5-dimethylthiophene: Communication 2. Action of amines of 3,4-bischloromethyl-2,5-dimethylthiophene

Published Mar 1, 1961 · Y. Gol'dfarb, M. S. Kondakova

Russian Chemical Bulletin

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Abstract

1. The reactions of 3,4-bischloromethyl-2,5-dimethylthiophene with various primary and secondary amines were studied. They resulted in the formation mainly of symmetrical bissecondary and bistertiary amines of structure (IV, (V), and (VII); no compounds analogous in structure to isoindoline were found among the reaction products. 2. Together with the diamines (IV), (V), and (VII), dithienodiazecines of structure (IXa) and (IXb) were obtained. 3. The action of methylating agents on the diamines (IV) gave the corresponding tertiary amines (IV) and their bisquaternary salts. 4. By the action of methyl iodide on the bistertiary amines (V), (VI), and (VII) in methanol, di- and monomethiodides were formed.

Study Snapshot

2,5-dimethylthiophene reacts with various amines to form symmetrical bissecondary and bistertiary amines, dithienodiazecines, and tertiary amines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of bifunctional derivatives from 2,5-dimethylthiophene: Communication 2. Action of amines of 3,4-bischloromethyl-2,5-dimethylthiophene

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