Hongwu Gao, A. Renslo
Oct 4, 2007
Citations
0
Influential Citations
8
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient and scalable synthesis of three differentially protected 2-(hydroxymethyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries.