V. Gouge, P. Jubault, J. Quirion
Jan 19, 2004
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 2,2-Difluoro-3-(2-hydroxy-1 R -phenylethylamino)-3 S -phenylpropionic acid 3 , obtained by a Reformatsky-type reaction of ethyl bromodifluoroacetate with (4 R )-2,4-diphenyloxazolidine, was used as a classical carboxylic acid in the Ugi reaction to prepare various difluorinated pseudopeptides 5a – n . Compounds 5 were then deprotected by hydrogenolysis to furnish difluorinated pseudopeptides 6 .