Synthesis of uridine diphosphate-glucuronic acid.

doi:10.1248/CPB.8.750

Paper

Synthesis of uridine diphosphate-glucuronic acid.

Published Aug 25, 1960 · M. Honjo, Y. Furukawa, K. Imai

Chemical & pharmaceutical bulletin

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2

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0

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Abstract

Uridine 5'-phosphoramidate (I) was allowed to react with α-glucuronic acid 1-phosphate (II), and α-uridine diphosphate glucuronic acid (α-UDPGA) (III) was isolated from the reaction mixture by ion exchange chromatography. Likewise, β-UDPGA (V) was produced from (I) and β-glucuronic acid 1-phosphate (IV). Formation of (III) was also observed by the oxidation of α-uridine diphosphate glucose (VI) in the presence of platinum oxide catalyst. Ability of (III) and (V) to form o-aminophenolglucuronide was examined with the transferase in microsomes of a guinea pig liver ane only (III) was found to be active. This fact indicated that natural UDPGA takes the same configuration as (III).

Study Snapshot

-uridine diphosphate glucuronic acid (-UDPGA) is the active, natural form of uridine diphosphate-glucuronic acid, with its configuration being the same as that found in guinea pig liver microsomes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of uridine diphosphate-glucuronic acid.

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References

Citations

Glycosidase activities of the hepatopancreas of the ascidian Pyura stolonifera.

The hepatopancreas of the ascidian Pyura stolonifera contains a wide range of polysaccharidase activities and hydrolyzes various aryl glycosides, acting as a transferase.

Glucuronide-Forming Enzymes

Glucuronide-forming enzymes play a crucial role in cellular transport and metabolism, with their importance in glucuronide-mediated conjugation being the most common conjugation in mammals.