Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

doi:10.3390/molecules15053634

Paper

Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

Published May 1, 2010 · Chunxiao Ji, Feng-lian Ren, Jun Dai

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Abstract

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.

In Vitro Study

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1,2-bis(2-methylallyl)disulfane significantly inhibits human HepG2 cell proliferation and induces apoptosis, making it a potential cancer drug.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

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