Li Ming-zhu
2012
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Journal
Journal of Yanbian University
Abstract
To discuss the effects of ethyl 2-[1-(pyridin-2-yl)ethoxy]acetamides on learning and memory facilitation in mice.2-(1-bromoethyl)pynidine(2) was obtained through Whol-ziegler reaction using 2-ethylpyridine(1) as the starting material,which further reacted with sodium 2-ethoxy-2-oxo-ethanolate to give ethyl[2-(1-(pyridine-2-yl)ethoxy)]acetate(3).The compounds 4-9 were obtained through the aminolysis of compound 3.Compound 3 was hydrolyzed under alkaling conndition to get compound 10.Compound 10 was treated with SOCl2,and further reacted with different substituted phenylamine to obtain compounds 12-13,respectively.The results show that the eight target compounds designed and synthesized are all new compounds,and the structures of them are confirmed by IR,1H-NMR and MS spectrum.The effect of compounds on learning and memory in mice was tested using water maze test,and the pharmacological results show the compound 8 shows strong learning and memory facilitation in mice.