R. Begum, M. Rehman, K. Shahid
Jun 1, 2021
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Influential Citations
7
Citations
Journal
Journal of Molecular Structure
Abstract
ABSTRACT Four new nickel(II) mixed ligand bicarboxylate complexes of the formulae [Ni(para-nitrocinnamate)2(Pyridine)2(H2O)2] (1), [Ni(cinnamate)2(Pyridine)2(H2O)2] (2), [Ni(para-methylcinnamate)2(2,2ʹ-bipyridine)(H2O)2] (3) and the co-crystal {[Ni(para-methyl-cinnamate)2(ethylenediammine)2].[Ni(ethylenediammine)2](para-methylcinnamate)2.H2O} (4), have been synthesized by reacting nickel acetate and sodium salt of cinnamic acid and its substituted derivatives in aqueous medium. The ligands used in this study were cinnamic acid, 4-methylcinnamic acid, 4-nitrocinnamic acid, 2, 2′-bipyridine, pyridine and ethylene diamine. The appearance of new vibrational bands for Ni-N and Ni-O (550-480 cm−1, 430-410 cm−1) in the IR spectra indicated formation of nickel(II) carboxylate mixed ligands complexes. Single crystal X-ray analysis confirmed distorted octahedral geometry for all the complexes 1-4. Complex 4 is a co-crystal with unique properties. Viscometery and UV-Visible spectroscopy studies were carried out to find out the DNA-binding ability of all synthesized complexes. By using these techniques the binding constant of the order of 104 M−1 and negative value for ΔG were calculated showing spontaneity of complex-DNA binding. All the synthesized complexes exhibited significant antibacterial as well as antifungal inhibition activities against three bacterial and three fungal strains. These preliminary findings herald a big hope for the further exploration of these and structurally similar complexes.