F. Shaheen, Saqib Ali, S. Rosario
Mar 26, 2014
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Journal
Journal of Coordination Chemistry
Abstract
Trimethyl (1), tributyl (2), and triphenyl tin (3) derivatives of sodium (R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (sodium deoxycholate) were synthesized by refluxing sodium deoxycholate with the corresponding triorganotin(IV) chloride in 1 : 1 M ratio. All the three compounds were characterized by elemental analysis, infrared spectroscopy, 1H, 13C, 119Sn NMR, and X-ray diffraction studies. From FT-IR spectra, Δν values proposed bridging or chelating behavior of the ligand. The three compounds gave a trigonal bipyramidal geometry in the solid state and tetrahedral geometry in solution. Single crystal of 1 showed polymeric trigonal bipyramidal geometry. Synthesized compounds obtained were screened for their antimicrobial and antitumor activities against A2780 cell line. Results revealed that only 2 showed significant antibacterial activity. However, all the three compounds exhibited promising antifungal and anticancer activities. Graphical Abstract The synthesized compounds inhibit strong antifungal activity even higher than the standard drug, Turbinafine. Keeping in view their antifungal activity, they might be used as potent antifungal agent.