I. A. Natchev
1988
Citations
0
Influential Citations
26
Citations
Journal
Tetrahedron
Abstract
Abstract The unusual natural amino acid 3,4-didehydro-5-phosphono-D-norvaline, D4, and the cyclic analogue 14 have been synthesized by four- and three-component condensation of the aldehydes 3 and 10 , respectively. Strict selectivity has been observed in the enzyme-substrate interactions with the enzymes phosphodiesterase I, alkaline phosphatase, α-chymotrypsin, urease, and alkaline mesintericopeptidase. The tripeptide antibiotics Plumbemicin A, 21 , and B, 25 , have been synthesized by the methods of conventional peptide synthesis and enzyme-catalyzed removal of the protective groups. Biological tests of the newly synthesized compounds have shown that they possess herbicidal, fungicidal, and antitumour activity.