L. Horrocks, Anna Radominska-Pyrek
May 1, 1972
Citations
0
Influential Citations
27
Citations
Journal
FEBS Letters
Abstract
suggested that 1 -alkyl-2-acyl-sn-glycero-3-phosphorylethanolamines (alkylacyl-GPE) are ;he immediate precursors of 1 alkenyl-2-acyl-sn-glycero-3-phosphorylethanolamines (ethanolamine plasmalogens). The first direct evidence for the existence of an enzyme catalyzing this conversion was reported in 1972 by Paltauf [ 111 for microsomes from hamster intestinal mucosa. While studying the enzymic synthesis by rat brain microsomes of alkylacyl-GPE [12, 131 , we obtained Indirect evidence for the further conversion of these products to ethanolamine plasmalogens. By incubations of alkylacyl-GPE with fresh rat brain microsomes, we have detected a dehydrogenase that catalyzes the last step in the biosynthesis of ethanolamine plasmalogens .