H. Blaser, H. Hönig, M. Studer
Mar 5, 1999
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0
Influential Citations
56
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Journal
Journal of Molecular Catalysis A-chemical
Abstract
Ethyl nicotinate was hydrogenated to ethyl nipecotinate in two steps. In the first step, the starting material was converted to the 1,4,5,6-tetrahydro derivative with PdrC and hydrogen in 76% yield. The hydrogenation of this intermediate was investigated with both unmodified and 10,11-dihydrocinchonidine modified noble metal catalysts and the influence of the catalyst metal, support, solvent and modifier concentration was tested. Catalyst activity was low in all cases, probably because the C5C double bond is part of a vinylogeous carbamate. The highest activity was observed with Rh and RhrPt .