Wang Jin-ji
2014
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Journal
Chemical Research and Application
Abstract
Ethyl(R)-3,3-dimethyl-2-hydroxy-4-oxobutyrate was synthesized by asymmetric aldol reaction using ethyl glyoxylate and isobutyraldehyde as raw material. The effects of aldol reaction conditions,including the type and amount of catalyst,reaction time,reaction solvent,were investigated. The optimal conditions were as follows:L-histidine as catalyst at an amount of 30% of the molar ratio of ethyl glyoxylate. The yield of(R)-3,3-dimethyl-2-hydroxy-4-oxobutyric acid ethyl ester reached 75% in which the enantionselectivity(e. e)of the product gained 73%. The product was characterized by1 H NMR and GC-MS.