Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

doi:10.1016/J.BMC.2007.01.017

Paper

Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

Published Mar 15, 2007 · Nishida Jun, G. Hong, Kawabata Jun

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

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Study Snapshot

2',4',6'-trihydroxychalcones show high inhibitory effects on tyrosinase, with 15 being the most active, surpassing 2,2',4,4'-tetrahydroxychalcone and kojic acid.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

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References

DPPH Radical Scavenging Reaction of Hydroxy- and Methoxychalcones

DPPH radical scavenging activity of hydroxy- and methoxychalcones is significantly affected by the solvent used, potentially due to differences in readiness for cyclization to aurones and flavanones.

Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety.

The 2,4-substituted resorcinol subunit on ring B of tetrahydroxychalcones is crucial for their inhibitory potency, which can be optimized for designing effective whitening agents.

Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.

Chalcones are potentially potent new depigmentation agents due to their combination of tyrosinase inhibition and antioxidant activity, with Butein being the most potent.

Tyrosinase inhibitor from black rice bran.

The ethyl acetate extract of black rice bran contains protocatechuic acid methyl ester, a potent tyrosinase inhibitor with potential therapeutic applications.

Chemical and instrumental approaches to treat hyperpigmentation.

Depigmenting compounds should selectively target hyperactivated melanocytes without side effects, and standardized protocols are needed to evaluate their efficacy and safety.

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