Synthesis and biological evaluation of 2- and 4-hydroxymestranol

doi:10.1016/0039-128X(77)90025-3

Paper

Synthesis and biological evaluation of 2- and 4-hydroxymestranol

Published Sep 1, 1977 · R. Kanojia

Steroids

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4

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0

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Abstract

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Study Snapshot

2- and 4-hydroxymestranol show oral estrogenicity and contragestational activity in rats when synthesized using m-chloroperbenzoic acid.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and biological evaluation of 2- and 4-hydroxymestranol

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References

Convenient large scale preparation of catechol estrogens

This study presents a new inverse oxidation procedure for large-scale preparation of catechol estrogens, resulting in high yields of both 2 and 4-hydroxylated estrogens.

4-Hydroxyestrone: A new metabolite of estradiol-17β from humans

4-Hydroxyestrone is a new urinary metabolite of estradiol-17 in humans, accounting for 1.1% of the - 14 C dose in a 23-year-old woman and 0.51% in a 39-year-old man.

A relationship between estrogenicity and antifertility activity of 1-diphenylmethylenyl-2-methyl-3-ethyl-4-acetoxycyclohexane (ORF 8511) and similar nonsteroidal anti-implantive agents.

ORF 8511 and similar nonsteroidal compounds may owe their postcoital antifertility activity to their estrogenicity, with estrogens acting as pharmacological agents only in species with low normal endogenous estrogen titres.

A simple chemical method for the synthesis of catechol estrogens.

A simple one-step chemical reaction using potassium nitrosodisulfonate effectively synthesizes catechol estrogens, with structures established through NMR, UV, infrared, and mass spectroscopy.

Metabolism of radioactive 17α-ethynylestradiol by women

Women can efficiently metabolism radioactive 17-ethynylestradiol, producing urinary metabolites with less D-homoannulation than previously reported in rabbits.

Citations