Paper
Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.
Published Jul 1, 2015 · F. Wang, Zhuang Yang, Yibin Liu
Bioorganic & medicinal chemistry
Q2 SJR score
32
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Compound 8a, a microtubule targeting antitumor agent, shows promising antitumor activity by blocking cell cycle progression and causing cellular apoptosis in cancer cells.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors.
Novel millepachine derivatives show promising anticancer activity and potential for oral delivery, with 8 showing the most potent activity against cancer cells and maintaining activity in multidrug-resistant cancer cells.
2014·48citations·Zhuang Yang et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.
Compound 3c, a new antimitotic agent with potential clinical potential, shows promising antitumor activity in vivo, nearly eliminating hepatocellular carcinoma growth in Balb/c mice.
2014·53citations·R. Romagnoli et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents.
Barbigerone analogues show potential as anti-proliferative and anti-angiogenesis agents, with compound 13a showing the most potent inhibitory effect on cell proliferation and angiogenesis.
2014·8citations·Guangcheng Wang et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.
Our virtual screening approach identified a potent new chemotype of antiproliferative compounds with potential vascular disrupting agent properties.
2014·46citations·M. Canela et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site
4-(N-cycloamino)phenylquinazolines show potential as novel tubulin-polymerization inhibitors targeting the colchicine site, with potential antitumor activity.
2014·56citations·Xiao-Feng Wang et al.·Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Citations
Overview of the epigenetic/cytotoxic dual-target inhibitors for cancer therapy.
Combining epigenetic inhibitors with cytotoxic agents or designing dual-target inhibitors targeting both epigenetic and cytotoxic pathways may improve clinical efficacy and overcome resistance in cancer therapy.
2025·0citations·Hailiu Liang et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
An efficient and green synthesis of dihydrothiazolo [3,2-a] purine-2 (1H)-one derivatives using bleaching earth clay (BEC) as a recyclable catalyst and study of antibacterial potency
The one-pot method using bleaching earth clay (BEC) as a recyclable catalyst in PEG-400 produces green, efficient, and antibacterial dihydrothiazolo [3,2-a] purine-2(1H)-one derivatives with marked potency against bacteria.
2024·0citations·Prashant P. Mogle et al.·Journal of the Iranian Chemical Society
Journal of the Iranian Chemical Society
Development of New 5‐(Oxazol‐2‐yl)Pyrimidine Derivatives with Promising Anticancer Activities
New oxazolyl-pyrimidine derivatives show promising anticancer activities, with compounds 11 a and 11 b showing superior potency against cervical and lung cancer cell lines, and methoxy substituted derivatives showing excellent to good cytotoxic properties.
2023·1citation·Gajula Shyam Kumar et al.·ChemistrySelect
ChemistrySelect
Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole–Pyrimidine Derivatives as Potential Antiproliferative Agents
Compounds 4a, 4b, and 4h with substituted piperazine show promising antiproliferative activity and potential anticancer activity against various cancer cell lines.
2023·3citations·Ashraf K. El-Damasy et al.·Medicina
Medicina
Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent
LASSBio-1920 shows promising colorectal anticancer activity and pharmacokinetic properties, with excellent absorption and high central nervous system permeability.
2023·0citations·C. J. Guimarães et al.·Pharmaceutics
Pharmaceutics
Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
Triazinone-linked combretastatin analogues loaded on PEG-PCL modified diamond nanoparticles show enhanced solubility and antiproliferative activity against MDA-MB-231 breast cancer cells.
2022·13citations·I. Zaki et al.·Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural cytostatic combretastatin A-4: efficient routes of synthesis, tubulin inhibition, and cytotoxicity
Combretastatin A-4 analogs show potential as effective cancer cell inhibitors, with efficient synthesis methods and low cytotoxicity.
2021·1citation·R. K. Kostin et al.·Chemistry of Heterocyclic Compounds
Chemistry of Heterocyclic Compounds
Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies.
Most promising compounds identified in this review contain thiazole nuclei or derivatives, showing antiproliferative and antitumor activities.
2021·34citations·Nancy Guerrero-Pepinosa et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors.
[1,3]thiazolo[4,5-e]isoindoles show potential as antimitotic drugs by inhibiting tumor cell proliferation and causing cell cycle arrest and apoptosis in HeLa cells.
2020·25citations·V. Spanò et al.·European journal of medicinal chemistry
European journal of medicinal chemistry