S. Gupta, A. Tiwari, N. Upmanyu
Nov 15, 2014
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Abstract
Wide range of biological activities is associated with 1, 4-dihydropyrimidines/ pyrimidines, individually or in combination. In view of this, the present study, was an attempt to synthesize a molecules, Ethyl-2 [(substituted thio) 1, 4 dihydro 6 methyl 4phenyl] 5 pyrimidine carboxylate, with improved biological activity, lesser toxicity with undesirable side effects in clinical use. All the synthesized compounds have been characterized by using IR, 1H NMR and elemental analysis. Further, some compounds were screened for anti-ulcer activity. Compound AT4 has shown maximum anti-ulcer activity as compared to control group.