D. Anekal, J. S. Biradar
May 1, 2017
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0
Influential Citations
7
Citations
Journal
Arabian Journal of Chemistry
Abstract
A series of Ethyl 2-(2-(2,5-disubstituted-1H-indol-3-yl)-4-oxothiazolid-3-ylamino)-5,6- dihydro-5-oxo-4H-1,3,4-thiadiazine-6-carboxylates (4a-g) were synthesized from cyclocondensa- tion of Ethyl 2-{(2E)-2-((2,5-disubstituted-1H-indol-3-yl) methy leno) hydrazine}-5-oxo-5,6-dihy- dro-4H-1,3,4-thiadiazine-6-carboxylates (3a-g) with thioglycolic acid in the presence of the catalytic amount of zinc chloride. The compounds 3a-g were obtained from the reaction of Ethyl 2-hydrazinyl-5,6-dihydro-5-oxo-4H-1,3,4-thiadiazine-6-carboxylate (2) with various substituted indole-3-carboxaldehydes 1a-g. Newly synthesized compounds were characterized by using IR, 1 H NMR, Mass spectral and analytical data. Title compounds were evaluated for their in vitro anti- microbial activities against various microbial strains and selected compounds were tested for their analgesic and anti-inflammatory activities. Some of the newly synthesized Indolyl 4-thiazolidinone analogues displayed significant activity towards antimicrobial, analgesic and anti-inflammatory activities.