Synthesis and biological evaluation of novel pyrazolo[3,4-b]pyridines as cis-restricted combretastatin A-4 analogues.

doi:10.1016/j.bmcl.2020.127025

Paper

DOI: 10.1016/j.bmcl.2020.127025

Synthesis and biological evaluation of novel pyrazolo[3,4-b]pyridines as cis-restricted combretastatin A-4 analogues.

Published Feb 11, 2020 · Xie-Er Jian, Fang Yang, Cui-Shan Jiang

Bioorganic & medicinal chemistry letters

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Novel pyrazolo[3,4-b]pyridine analogues show potential as potent tubulin inhibitors for developing potent anticancer agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/j.bmcl.2019.126816

Design, synthesis and biological evaluation of novel indole-based oxalamide and aminoacetamide derivatives as tubulin polymerization inhibitors.

Novel indole-based oxalamide and aminoacetamide derivatives show potential as anticancer scaffolds by inhibiting tubulin polymerization and exhibiting antiproliferative effects against various cancer cell lines.

2019·20citations·Pengcheng Diao et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/j.ejmech.2019.111577

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.

Novel combretastatin A-4 analogues show potential as potent tubulin polymerization inhibitors and show potential in vivo antiproliferative effects against various cancer cell lines.

2019·21citations·R. Romagnoli et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/j.bioorg.2019.103260

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities.

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives show potent antitumor activity and potential as a new class of tubulin polymerization inhibitors for potential anticancer agents.

2019·63citations·Fang Yang et al.·Bioorganic chemistry

Bioorganic chemistry

DOI: 10.1016/j.bmcl.2019.04.035

Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization.

D4-9-31 resistance in ovarian cancer cells is linked to increased mitochondrial respiration and distinct mechanisms, with no cross-resistance to other microtubule targeting agents.

2019·3citations·J. C. Fox et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/j.ejmech.2018.12.053

3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation.

The most potent compound in this scaffold, 13d, significantly inhibits tubulin polymerization and disrupts cytoskeleton, targeting the colchicine site and potentially being a promising anticancer agent.

2019·25citations·Min'an Zhai et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

Citations

DOI: 10.30574/gscarr.2024.20.1.0248

Pyrimidine derivatives: Recent discoveries and development towards its medicinal impact

Pyrimidine derivatives show potential in treating various ailments, including cancer, infectious diseases, and metabolic disorders, with recent developments in synthesis and biological assessment.

2024·1citation·SABIU RABILU ABDULLAHI et al.·GSC Advanced Research and Reviews

GSC Advanced Research and Reviews

DOI: 10.3389/fchem.2024.1447831

Design, synthesis, and bioevaluation of diarylpyrimidine derivatives as novel microtubule destabilizers

Diarylpyrimidine derivatives show high selectivity against cancer cells by inhibiting tubulin polymerization, offering a new approach for developing tubulin-targeting anticancer drugs.

2024·0citations·Yutao Xiu et al.·Frontiers in Chemistry

Frontiers in Chemistry

DOI: 10.3390/molecules29133004

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

The chromenopyridine scaffold offers a versatile platform for drug design, with novel synthetic strategies promising promising biological activity.

2024·0citations·Fábio Pedroso de Lima et al.·Molecules

Molecules

DOI: 10.3390/cryst14060486

Novel Quaternary Ammonium Aldimine Derivatives Featuring 3,4,5-Trimethoxy Phenyl Fragment: Synthesis, Crystal Structure and Evaluation of Antioxidant and Antibacterial Activity

Novel quaternary ammonium aldimines show selective antibacterial activity against Gram-negative K. pneumoniae and P. aeruginosa, with no activity detected against E. coli and S. aureus.

2024·0citations·R. Rusew et al.·Crystals

Crystals

DOI: 10.1016/j.ejmech.2024.116497

Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells.

Combretastatin A-4 piperazine derivatives show potential as anti-colon carcinoma agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 and A549 cancer cells with low toxicity to normal cells.

2024·0citations·Hangqi Zhang et al.·European journal of medicinal chemistry

European journal of medicinal chemistry