M. Patel, J. Akbari, D. H. Purohit
Aug 12, 2008
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Influential Citations
3
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Quality indicators
Journal
ChemInform
Abstract
Various 3-(2-amino-6-arylpyrimidin-4-yl)-6-chlorocinnolin-4(3H)-one (2a-j) and 6-chloro-3-(6-aryl-2-mercapto-3,4-dihydropyrimidin-4-yl)cinnolin-4(3Η)-one (3a-j) were synthesized by the reaction of 6-chloro-3-[(2E)-3-arylprop-2-enoyl]-cinnolin-4(3H)-ones (la-j) with guanidine hydrochloride and thiourea respectively. All newly synthesized compounds were tested against different microbes for their antimicrobial activity and Mycobacterium tuberculosis for their antitubercular activity.