Synthesis and Evaluation of 4-(2-Chloroquinolin-3-Yl)-6-(6-Methyl-1H-Benzimidazol-2-Yl)Pyrimidin-2-Amines as Potent Anthelmintic Agents

doi:10.46624/ajptr.2018.v8.i6.015

Paper

Synthesis and Evaluation of 4-(2-Chloroquinolin-3-Yl)-6-(6-Methyl-1H-Benzimidazol-2-Yl)Pyrimidin-2-Amines as Potent Anthelmintic Agents

Published Dec 8, 2018 · B. Shivakumar, Indira. M. Madawali, S. Hugar

American Journal of PharmTech Research

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Abstract

A new series of 4-(2-chloroquinolin-3-yl)-6-(6-methyl-1H-benzimidazol-2-yl)pyrimidin-2-amine (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1Hbenzimidazol-2-yl)prop-2-en-1-one (IVa-k) with guanidine nitrate in ethanol and aqueous solution of sodium hydroxide. The synthesized compounds were characterized by their IR, H NMR and Mass spectral studies. The synthesized compounds were evaluated for anthelmintic activity by invitro method, against south Indian adult earth worms Pheretima posthuma using Albendazole as a standard drug. Results of the activities reveal that, compounds exhibited moderate to good anthelmintic activity.

Study Snapshot

4-(2-chloroquinolin-3-yl)-6-(6-methyl-1H-benzimidazol-2-yl)pyrimidin-2-amines show moderate to good anthelmintic activity against South Indian adult earth worms Pheretima posthuma.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Evaluation of 4-(2-Chloroquinolin-3-Yl)-6-(6-Methyl-1H-Benzimidazol-2-Yl)Pyrimidin-2-Amines as Potent Anthelmintic Agents

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Citations

Synthesis, In-vitro and In-silico Anti-inflammatory activity of new Thiazole derivatives

New thiazole derivatives show excellent to moderate anti-inflammatory activity, with high inhibition constant and binding energy, supporting their potential use in pharmaceuticals.