B. Shivakumar, Indira. M. Madawali, S. Hugar
Dec 8, 2018
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Journal
American Journal of PharmTech Research
Abstract
A new series of 4-(2-chloroquinolin-3-yl)-6-(6-methyl-1H-benzimidazol-2-yl)pyrimidin-2-amine (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1Hbenzimidazol-2-yl)prop-2-en-1-one (IVa-k) with guanidine nitrate in ethanol and aqueous solution of sodium hydroxide. The synthesized compounds were characterized by their IR, H NMR and Mass spectral studies. The synthesized compounds were evaluated for anthelmintic activity by invitro method, against south Indian adult earth worms Pheretima posthuma using Albendazole as a standard drug. Results of the activities reveal that, compounds exhibited moderate to good anthelmintic activity.