Zhang Guo-fu
2012
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Journal
Journal of Zhejiang University of Technology
Abstract
2-(Hydroxy-phenyl)-acetic acid methyl ester,which was obtained by esterification from(2-hydroxy-phenyl)-acetic acid,reacted with 3,4-dihydro-2H-pyran to give 2-[(tetrahydro-2H-pyran-2-yl)oxy]-methyl ester.And then it reacted with tert-butyl nitrate ester and iodomethane to get the target product,methxyl-2-(methoxyimino)-2-[2-(tetrahydro-2H-pyran-2-yloxy)phenyl]-acetate.The synthetic route has the advantages of easily operation,mild reaction conditions and high yield.The total yield was 63.4%with purity of 97.9% and the structure of product was identified by IR and 1H NMR.