Synthesis of highly functionalized 2,4-diaminoquinazolines as anticancer and anti-HIV agents.

doi:10.1016/j.bmcl.2010.06.056

Paper

DOI: 10.1016/j.bmcl.2010.06.056

Synthesis of highly functionalized 2,4-diaminoquinazolines as anticancer and anti-HIV agents.

Published Aug 1, 2010 · Shengjiao Yan, Hang-Jun Zheng, Chao Huang

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

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Highly functionalized 2,4-diaminoquinazolines show potent anticancer and anti-HIV activity, with 5a showing the most potent cytotoxic activity against tumor cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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