Synthesis and anti-juvenile hormone activity of ethyl 4-[(6-substituted 2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoates

doi:10.1584/JPESTICS.G09-71

Paper

Synthesis and anti-juvenile hormone activity of ethyl 4-[(6-substituted 2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoates

Published Nov 25, 2010 · Kenjiro Furuta, N. Fujita, Tsubasa Ibushi

Journal of Pesticide Science

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Abstract

Ethyl 4-[(6-substituted 2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoates and their analogues were prepared and the biological activities were evaluated for both anti-juvenile hormone (anti-JH) and JH activity in silkworm larvae, Bombyx mori. Of the compounds tested, ethyl 4-[(6-methoxy-2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoate (3b) showed the most effective precocious metamorphosis-inducing activity in 3rd instar larvae and JH activity in allatectomized 4th instar larvae. Furthermore, JH I and 20-hydroxyecdysone (20-E) titers in hemolymph of 3rd instar larvae treated with 3b were measured by liquid chromatography-mass spectrometry (LC-MS) and LC-MS/MS, respectively. The results revealed that compound 3b induced precocious metamorphosis by specifically decreasing JH I in hemolymph.

Study Snapshot

Ethyl 4-[(6-methoxy-2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoate (3b) effectively induces precocious metamorphosis in silkworm larvae by specifically decreasing juvenile hormone I in hemolymph.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and anti-juvenile hormone activity of ethyl 4-[(6-substituted 2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoates

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References

Citations

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Determination by LC-MS of Juvenile Hormone Titers in Hemolymph of the Silkworm, Bombyx mori

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