E. Chalina, Lidia Chakarova, D. Staneva
Dec 1, 1998
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0
Influential Citations
12
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Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract Some new 1,3-disubstituted ureas and phenyl N-substituted carbamates were prepared and evaluated in vivo for their antiarrhythmic and hypotensive properties. The compound 1-tert.-butyl-1-(3-cyclopentyloxy-2-hydroxypropyl)-3-methylurea 2c exhibited a strong hypotensive action. The compounds 2-(1-tert.-butyl-3-methylureido)-1-(cyclopentyloxymethyl)ethyl N-isopropylcarbamate 3c and 2-(1-tert.-butyl-3-ethylureido)-1-(cyclopentyloxymethyl)ethyl N-isopropylcarbamate 3f showed an antiarrhythmic activity comparable to that of the reference drug Propranolol.