S. Fazylov, O. Nurkenov, T. Zhivotova
Oct 1, 2016
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Journal
Pharmaceutical Chemistry Journal
Abstract
Three-component condensation of thiourea, ethyl acetoacetic ester, and anisaldehyde was performed to synthesize ethyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound interacted with aromatic aldehydes to yield the corresponding styryl derivatives. The hypotensive activity of the compounds synthesized here was assessed.