Paper
Synthesis, identification and antiplatelet evaluation of 2-morpholino substituted benzoxazines.
Published Sep 1, 2007 · Kaylene M. Pritchard, J. Al‐Rawi, C. Bradley
European journal of medicinal chemistry
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34
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0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
2-morpholino substituted benzoxazines show potent activity against ADP and collagen-induced platelet aggregation, with structures confirmed by microanalysis and NMR.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Two chromen-4-one compounds, 2-N-morpholino-8-dibenzofuranyl-chromen-4-one and 2-N-morpholino-8-dibenzothiophenyl-chromen-4-one, show excellent DNA-PK inhibitory activity and can sensitize cells to
2005·152citations·I. Hardcastle et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Generalized Method for the Production of 1,3‐Benzoxazine, 1,3‐Benzothiazine, and Quinazoline Derivatives from 2‐(Hydroxy, Thio, or Amino) Aromatic Acids Using Triphenylphosphine Thiocyanogen
A modified one-pot method allows for the synthesis of 1,3-benzoxazines, 1,3-benzothiazine, and quinazoline derivatives from 2(Hydroxy, Thio, or Amino) aromatic acids using triphenylphosphine thi
2005·23citations·Kaylene M. Pritchard et al.·Synthetic Communications
Synthetic Communications
4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands.
4-(2-methylaminoethoxy)-N-(phenylsulfonyl)indole 5g shows high affinity and selectivity for the 5-HT6 receptor, offering potential for pharmaceutical applications.
2005·22citations·P. Zhou et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
The most potent DNA-PK inhibitor, NU7163, shows ATP-competitive inhibition and selectivity, sensitizing human tumor cells to ionizing radiation.
2005·139citations·R. Griffin et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
NU7441 is a highly potent and selective DNA-dependent protein kinase inhibitor with ATP-competitive inhibition kinetics, offering potential therapeutic applications in cancer treatment.
2004·388citations·Justin J. J. Leahy et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.
LY294002 effectively inhibits PDE2 and PDE3, suggesting potential for use in anti-platelet therapies.
2004·26citations·Belinda M. Abbott et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Anti-platelet and membrane-rigidifying flavonoids in brownish scale of onion
The brownish scale of onion contains anti-platelet and membrane-rigidifying flavonoids, which may be a potential medicinal resource for treating blood clots and other conditions.
2003·65citations·M. Furusawa et al.·Journal of Health Science
Journal of Health Science
NMR Study of Substituted 1‐Bromo‐2‐aryloxyethanes and Monosubstituted Xanthones
Substituted 1bromo-2aryloxyethanes and monosubstituted xanthones show similar substituent effects to 3aryloxypropiononitriles, with spectral assignments based on comparisons of coupled and 1H-decoupled 13
1996·11citations·A. Pomilio et al.·Magnetic Resonance in Chemistry
Magnetic Resonance in Chemistry
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
LY294002 is a specific inhibitor of PtdIns 3-kinase, potentially benefiting treatment of proliferative diseases and understanding its role in growth factor signal transduction.
1994·3365citations·C. Vlahos et al.·The Journal of biological chemistry
The Journal of biological chemistry
Citations
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2023·6citations·Nidhi Gupta et al.·ChemistrySelect
ChemistrySelect
Synthesis and biological evaluation of 4H-benzo[e][1,3]oxazin-4-ones analogues of TGX-221 as inhibitors of PI3Kβ.
TGX-221 analogues with an CH(CH3)NH linker show comparable activity to TGX-221 as PI3K inhibitors, while those with an CH(CH3)O linker show less activity but still show useful SAR.
2022·2citations·Ehtesham U. R. Mohammed et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Medicinal chemistry of oxazines as promising agents in drug discovery
Oxazines show promising pharmaceutical and biological activities, including sedative, analgesic, anticonvulsant, antipyretic, antimicrobial, antitubercular, antimalarial, antioxidant, and anticancer properties.
2020·46citations·D. Zinad et al.·Chemical Biology & Drug Design
Chemical Biology & Drug Design
Synthesis of New Oxazin Compounds Derived from Furfural, Chalcons and Schiff Bases
New oxazine compounds were synthesized using various routes, including chalcone treatment, formaldehyde cyclization, and furfural-hydroxyl aromatic compounds in methanolic ammonia.
2019·3citations·Mohammad S Al Ajely·LOJ Pharmacology and Clinical Research
LOJ Pharmacology and Clinical Research
Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.
Novel quinazolin-4-one derivatives show potential as synergistic agents for doxorubicin cytotoxicity by affecting cell proliferation through DNA-PK and PARP-1 inhibition.
2019·3citations·M. Pospisilova et al.·Bioorganic chemistry
Bioorganic chemistry