Xianpei Wang, Lijuan Ma, Wei Yu
Aug 1, 2011
Citations
0
Influential Citations
16
Citations
Journal
Synthesis
Abstract
Imidazo[1,2- A]pyridine-3-carboxylatescan be prepared directly from 2-aminopyridines and β-ketoesters by using bis(acetyloxy)(phenyl)-λ 3 -iodaneas an oxidant and boron trifluoride etherate as a catalyst. Theamount of catalyst plays a key role in determining the course ofthe reaction. Whereas the use of 0.2 equivalents of catalyst ensuresthe generation of imidazo[1,2- A]pyridines,raising the amount of catalyst to 1.0 equivalents results in exclusive α-acetoxylationof the β-keto esters. 2-Aminopyridines can also react with1,3-diones to afford 3-acylimidazo[1,2- A]pyridines.