D. M. Lokeshwari, K. A. Kumar
2017
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Journal
Asian Journal of Chemistry
Abstract
In the present study, we report the synthesis of series of novel substituted isoxazoles via 1,3-dipolar cycloaddition reaction. Nitrile oxides generated by the catalytic dehydrogenation of aldoximes by chloramine-T, were trapped in situ by 4-(furan-2-yl)but-3-en-2-one to obtain an isomeric mixture of isoxazoles. The structure of the new isoxazoles were elucidated by spectral and elemental analyses. The synthesized isoxazoles have been screened in vitro for their DPPH radical scavenging abilities and antimicrobial activities. Amongst the synthesized series, compound 1-(3-(4-chlorophenyl)-4-(furan-2-yl)-4,5-dihydroisoxazol-5-yl)ethanone ( 4f ) exhibited excellent radical scavenging and antimicrobial susceptibilities.